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KMID : 0391020050130010037
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Journal of Korean Society for Clinical Pharmacology and Therapeutics
2005 Volume.13 No. 1 p.37 ~ p.44
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Two Cases of Galactorrhea Associated with Paroxetine
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Woo Doo-Hyun
Lee Hyang-Ie
Kim Yee-Hyung
Chon Suk
Koh Gwan-Pyo
Oh Seung-Joon
Woo Jeong-Taek
Kim Sung-Woon
Kim Jin-Woo
Kim Young-Seol
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Abstract
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Drugs are one of the most common causes that induce galactorrhea, though other various factors such as hypothalamic-pituitary disorders, idiopathic causes and some systemic diseases are known to cause galactorrhea. Among the medications, antidepressants, antihypertensives, phenothiazine and H2-blocker are known as common causes of non-puerperal lactation. Paroxetine is a potent antidepressant of SSRI (selective serotonin reuptake inhibitor) class, and there are few reports of galactorrhea induced by paroxetine. We experienced two cases of galactorrhea following treatment with paroxetine. In the first case, a 24-year-old woman, who took daily 10 mg paroxetine for her depression, developed galactorrhea four months later. Paroxetine was maintained because her depression continued. Thus bromocriptine, a dopamine agonist, was added to her regimen. The galactorrhea ceased approximately four weeks after the bromocriptine started. Thereafter paroxetine and bromocriptine were discontinued, and galactorrhea ceased. In the second case, a 30-year-old woman taking $10{\sim}20\;mg$ paroxetine daily to treat her post-traumatic syndrome, developed galactorrhea three months later. The medication was discontinued the next morning and the discharge ceased three weeks later. Both of the patients showed normal findings of brain MRI and their serum prolactin levels are 5.7 ng/mL and 7.5 ng/mL respectively. They all revealed hypersensitivity in TRH stimulation test.
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KEYWORD
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Galactorrhea, Paroxetine, Antidepressant
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